Rapamycin for Dogs With Cancer
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Rapamycin for Dogs with Cancer
If your pet has been diagnosed with cancer, please check in with me. Holistic cancer therapy is a passion of mine, and there are a number of ways to potentially help your pet. This includes rapamycin.
Rapamycin is commonly used to fight cancer in humans, and there are a number of ongoing clinical trials studying the use of rapamycin for dogs with cancer.
Rapamycin targets mTOR, an important regulator of cell division and tumor blood supply. By inhibiting mTOR, rapamycin can in theory reduce tumor growth, tumor nourishment, and tumor spread via new blood vessels. Learn more about how rapamycin works here.
Here’s a summary of using rapamycin for dogs with cancer….
Dr Kevin has been so helpful in the care of Simon our Goldendoodle, he has given us many suggestions to help our boy. Rapamycin has seemed to have given new life to our dog, and he is currently happy and thriving, two years post diagnosis. It is quite amazing. I highly recommend Dr Kevin, it is a pleasure working with you on his care.
Rapamycin for Dogs with Lymphoma
Study 1: the pAKT/mTOR pathway is present only in malignant, but not normal, lymphoblasts. A novel pAKT/mTOR inhibitor produced dose-dependent inhibition of malignant cell proliferation
Study 2: Low dose rapamycin inhibited lymphoma cell proliferation, while high dose rapamycin actively killed lymphoma cells.
Study 3: Aberrant mTOR regulation plays a role in many blood cancers, and thus mTOR inhibitors like rapamycin should be routinely considered in their management.
Rapamycin for Dogs with Hemangiosarcoma
Study 1: Low dose rapamycin inhibited HSA cell proliferation, while high dose rapamycin actively killed HSA cells.
Study 2: Inhibitors of the pI3K/AKT/mTOR pathways reduce the proliferation of canine HSA cells.
Study 3: In vitro effects of rapamycin on canine HSA cells
Clinical Trial on rapamycin and canine HSA
Rapamycin for Dogs with Osteosarcoma
Study 1: mTOR is a primary driver for osteosarcoma cell multiplication, so inhibiting mTOR with rapamycin may reduce tumor enlargement.
Study 2: This metastudy showed that rapamycin did not alter the course of canine osteosarcoma.
Clinical Trial on rapamycin for the adjunctive treatment of canine osteosarcoma
Rapamycin for Dogs with Melanoma
We have seen very good results in three cases of melanoma that were treated with continual rapamycin. One, my pal Joey from Iowa, has survived for 4 years to date.
Study 1: mTOR is present and active in multiplying melanoma cells. Rapamycin, through its mTOR inhibition, will inhibit melanoma cell proliferation and tumor growth.
Study 2: mTOR is present and active in melanoma skin tumors, and thus rapamycin and other mTOR inhibitors may be a logical intervention.
Rapamycin for Dogs with Mammary Cancer
Study 1: Low dose rapamycin inhibited mammary cancer cell proliferation, while high dose rapamycin actively killed mammary cancer cells.
Study 2: activated mTOR was not found in normal dog mammary tissue, but was present in 78% of canine mammary tumors.
Study 3: Overview of mTOR inhibition for breast cancer